CoroWise™ Plant sterols

Articles published in several peer-reviewed scientific journals demonstrate the clinical efficacy of free, unesterified plant sterols in individuals with elevated and normal serum cholesterol levels:

Christiansen LI, Lahteenmaki PL, Mannelin MR, Seppanen-Laakso TE, Hiltunen RV, and Yliruusi JK, 2001. Cholesterol-lowering effect of spreads enriched with microcrystalline plant sterols in hypercholesterolemic subjects. European Journal of Nutrition 40:66-73.

de Graaf J, de Sauvage Nolting PRW, van Dam M, Belsey EM, Kastelein JJP, Pritchard PH, Stalenhoef AFH, 2002. Consumption of tall oil-derived plant sterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels. British Journal of Nutrition 88:479-488

Jones, PJH, Ntanios, FY, Raeini-Sarjaz M, and Vanstone CA, 1999. Cholesterol-lowering efficacy of a sitostanol-containing plant sterol mixture with a prudent diet in hyperlipidemic men. American Journal of Clinical Nutrition 69:1144-50.

Meguro S, Higashi K, Hase T, Honda Y, Otsuka A, Tokimitsu I, Itakura H, 2001. Solubilization of plant sterols in diacylglycerol versus triacylglycerol improves the serum cholesterol-lowering effect. European Journal of Clinical Nutrition 55:513-517.

Nestel P, Cehun M, Pomeroy S, Abbey M, and Weldon G, 2001. Cholesterol-lowering effects of plant sterol esters and non-esterified stanols in margarine, butter and low-fat foods. European Journal of Clinical Nutrition 55:1084-1090.

Pelletier X, Belbraouet S, Mirabel D, Mordret F, Perrin JL, Pages X, and Debry G, 1995. A diet moderately enriched in plant sterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Annals of Nutrition and Metabolism 39:291-95.

Sierksma A, Weststrate JA, and Meijer GW, 1999. Spreads enriched with plant sterols, either esterified 4,4-dimethylsterols or free 4-desmethylsterols, and plasma total- and LDL-cholesterol concentrations. British Journal of Nutrition 82:273-82.

Volpe R, Niittynen L, Korpela R, Sirtori C, Bucci A, Fraone N, and Pazzucconi F. 2001. Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia. British Journal of Nutrition 86:233-9.